Deep and Deeper: Multiple Pathways in Basal

wnloaded s perspective places the report by Villani et al. that appears in this issue of the journal (beginning ge 1222) in the context of recent work showing an intersection between two important developl pathways implicated in oncogenesis: the hedgehog and insulin-like growth factor (IGF) pathVillani et al. define a key role for the IGF regulatory protein Igfbp2 in a genetic model of basal rcinogenesis driven by targeted constitutive activation of hedgehog signaling. Placed in the frameof other recently published work, the observations of Villani et al. both raise questions about the work cell of origin for basal cell cancers and define additional putative therapeutic and preventive targets for this disease. Cancer Prev Res; 3(10); 1213–6. ©2010 AACR.